Pathogenesis and therapeutic options of gallbladder carcinoma: Pathogenesis of GBC - Softcover
Gallbladder cancer is a rare disease that may be diagnosed incidentally cholecystectomy, often with more advanced disease. Jaundice is considered an ominous sign in the presentation of gallbladder cancer. The K-ras proto-oncogene is thought to exert control over some of the mechanisms of cell growth and differentiation. This gene is converted to an active oncogene by point mutations significantly concentrated in codons 12, 13, or 61. The Ras family consists of three genes located in different chromosomes, encoding the homologous 21 kDa proteins H-Ras, N-Ras and K-Ras. p53 acts as the single most important gene in cancer as a single mutation can lead to tumor genesis. p53 functions have been further diversified by the discovery of various isoforms of p53. These isoforms derived either by alternative splicing or by differential translational sites are expressed in a tissue specific manner. The influence of p53β isoform on p53 activity either by its transcriptional repression or by forming a complex with p53 thereby modulating its activity at p53 dependent promoters. The roles of adjuvant and neoadjuvant therapies in the treatment of gallbladder cancer remain poorly elucidated.
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- PublisherScholars' Press
- Publication date2018
- ISBN 10 3639762827
- ISBN 13 9783639762822
- BindingPaperback
- Number of pages52
- EditorSingh Govind
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Pathogenesis and therapeutic options of gallbladder carcinoma
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ISBN 13: 9783639762822
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Book Description Taschenbuch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Gallbladder cancer is a rare disease that may be diagnosed incidentally cholecystectomy, often with more advanced disease. Jaundice is considered an ominous sign in the presentation of gallbladder cancer. The K-ras proto-oncogene is thought to exert control over some of the mechanisms of cell growth and differentiation. This gene is converted to an active oncogene by point mutations significantly concentrated in codons 12, 13, or 61. The Ras family consists of three genes located in different chromosomes, encoding the homologous 21 kDa proteins H-Ras, N-Ras and K-Ras. p53 acts as the single most important gene in cancer as a single mutation can lead to tumor genesis. p53 functions have been further diversified by the discovery of various isoforms of p53. These isoforms derived either by alternative splicing or by differential translational sites are expressed in a tissue specific manner. The influence of p53beta isoform on p53 activity either by its transcriptional repression or by forming a complex with p53 thereby modulating its activity at p53 dependent promoters. The roles of adjuvant and neoadjuvant therapies in the treatment of gallbladder cancer remain poorly elucidated. 52 pp. Englisch. Seller Inventory # 9783639762822
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Pathogenesis and therapeutic options of gallbladder carcinoma : Pathogenesis of GBC
Published by
Scholars' Press
(2018)
ISBN 10: 3639762827
ISBN 13: 9783639762822
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Book Description Taschenbuch. Condition: Neu. nach der Bestellung gedruckt Neuware - Printed after ordering - Gallbladder cancer is a rare disease that may be diagnosed incidentally cholecystectomy, often with more advanced disease. Jaundice is considered an ominous sign in the presentation of gallbladder cancer. The K-ras proto-oncogene is thought to exert control over some of the mechanisms of cell growth and differentiation. This gene is converted to an active oncogene by point mutations significantly concentrated in codons 12, 13, or 61. The Ras family consists of three genes located in different chromosomes, encoding the homologous 21 kDa proteins H-Ras, N-Ras and K-Ras. p53 acts as the single most important gene in cancer as a single mutation can lead to tumor genesis. p53 functions have been further diversified by the discovery of various isoforms of p53. These isoforms derived either by alternative splicing or by differential translational sites are expressed in a tissue specific manner. The influence of p53beta isoform on p53 activity either by its transcriptional repression or by forming a complex with p53 thereby modulating its activity at p53 dependent promoters. The roles of adjuvant and neoadjuvant therapies in the treatment of gallbladder cancer remain poorly elucidated. Seller Inventory # 9783639762822
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Pathogenesis and therapeutic options of gallbladder carcinoma
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Book Description Condition: New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Autor/Autorin: Singh GovindDr. Govind Singh, M.D. (Biochemistry), Department of Biochemistry, GMC, Haldwani, Nainital, Uttarakhand. Dr. Sanjeev Kumar Shukla (Ph.D. Biotechnology), Multidisciplinary Research Unit (MRU), GMC, Haldwani, Nainital, Utta. Seller Inventory # 385760203
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Pathogenesis and therapeutic options of gallbladder carcinoma: Pathogenesis of GBC
Published by
Scholars' Press
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ISBN 10: 3639762827
ISBN 13: 9783639762822
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Book Description Paperback. Condition: Brand New. 52 pages. 8.66x5.91x0.12 inches. In Stock. Seller Inventory # 3639762827
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