Excerpt from The Johns Hopkins Alumni Magazine, Vol. 5: June, 1917
They formulated the problem with care and devised exact methods for the determination of results at each step. Dakin produced about two hundred antiseptic substances to be tested, and of them all the old-fashioned hypochlorites proved the best. Similar substances were already being used with considerable success by the Edinburgh University group. Carrel then devised, with the help of M. Du Noiiy, methods for the mathematical representation of the rate of healing, and the disappearance of the microorganisms was followed by a bacteriologist. The most important surgical problem was to maintain the constant presence of the anti septic solution in all parts of the wound in proper concen tration. This Carrel accomplished by a very complete opening up of the wound, and by the introduction of many small tubes, through which the solution was allowed to flow at regular intervals. Every detail was investigated with scrupulous care and the final method as it exists today de pends for its success largely upon minutiae of technic.
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