Excerpt from Study of the Cause of Sudden Death Following the Injection of Horse Serum
It has long been known that the blood of certain animals -is poisonous when transfused or injected into certain other species.
Many instances might be cited showing that the blood serum of one animal has poisonous properties when injected into an animal of another species. But the blood serum of the horse apparently lacks such poisonous action. Very large quantities of the blood serum of the horse may be injected into man, rabbits, guinea pigs, and many other animals Without serious inconvenience, except occasionally a slight reaction at the site of inoculation.
In a certain proportion of cases the injection of horse serum into man is followed by urticaria] eruptions, joint pains, fever, swelling of the lymph nodes, edema, and albuminuria. This reaction, which appears after an incubation period of eight to thirteen days, has been termed by Pirquet and Schick the serum disease.
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