Helix-Loop-Helix Transcription Factors (Protein Profiles) - Softcover

Littlewood, Trevor D.; Evan, Gerard I.

Softcover

ISBN 10: 0198502486 ISBN 13: 9780198502487

Publisher: Oxford University Press, 1998

Synopsis

Helix-Loop-Helix (HLH) proteins are involved in transcriptional regulation of gene expression. The HLH domain is a DNA-binding dimerization domain which mediates homodimerization and heterodimerization with other HLH proteins. This new volume in the Protein Profile series explores the sequence specificity of DNA binding, the nature of dimerization partners, the regulation of target genes by HLH proteins, and the negative regulation of some bHLH proteins by HLH proteins which lack a functional DNA-binding domain. Topics include the role of HLH proteins in such diverse areas as myogenesis, neurogenesis, haematopoeisis, and sex determination; tissue specific HLH proteins; the role of HLH proteins in yeast and plants; nuclear localization of HLH proteins, transactivation domains and post-translational modification.

About this title

About the Author:

Trevor Littlewood is at Imperial Cancer Research Fund Laboratories. Gerard Evan is at Imperial Cancer Research Fund.

About this edition

• Publisher: Oxford University Press
• Publication date: 1998
• ISBN 10: 0198502486
• ISBN 13: 9780198502487
• Binding: Paperback
• Edition number: 3
• Number of pages: 162